Evolutionary Landscape of the Mycobacterium tuberculosis Complex from the Viewpoint of PhoPR: Implications for Virulence Regulation and Application to Vaccine Development

Broset, Esther; Martı́n, Carlos; Gonzalo‐Asensio, Jesús

doi:10.1128/mbio.01289-15

Public

Evolutionary Landscape of the Mycobacterium tuberculosis Complex from the Viewpoint of PhoPR: Implications for Virulence Regulation and Application to Vaccine Development

Published in mBio • Oct 22, 2015

Authors:

Esther Broset

Carlos Martı́n

Jesús Gonzalo‐Asensio

Abstract

Different members of the Mycobacterium genus have evolved to cause tuberculosis in diverse human populations and in a variety of animal species. Our cumulative knowledge of mycobacterial genomes indicates that mutations in the PhoPR two-component virulence system were acquired not only during the na...

Subject

Virulence

Mycobacterium tuberculosis complex

Mycobacterium bovis

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