Genomic Characterization of Brain Metastases Reveals Branched Evolution and Potential Therapeutic Targets

K. Brastianos, Priscilla; L. Carter, Scott; Santagata, Sandro; P. Cahill, Daniel; Taylor‐Weiner, Amaro; T. Jones, Robert; M. Van Allen, Eliezer; S. Lawrence, Michael; Horowitz, Peleg; Cibulskis, Kristian; L. Ligon, Keith; Tabernero, Josep; Seoane, Joan; Martínez‐Sáez, Elena; T. Curry, William; F. Dunn, Ian; Ha Paek, Sun; Park, Sung‐Hye; McKenna, Aaron; Chevalier, Aaron; Rosenberg, Mara; G. Barker, Frederick; M. Gill, Corey; Van Hummelen, Paul; R. Thorner, Aaron; E. Johnson, Bruce; P. Hoang, Mai; K. Choueiri, Toni; Signoretti, Sabina; Sougnez, Carrie; S. Rabin, Michael; U. Lin, Nancy; P. Winer, Eric; Stemmer‐Rachamimov, Anat; Meyerson, Matthew; A. Garraway, Levi; Gabriel, Stacey; S. Lander, Eric; Beroukhim, Rameen; T. Batchelor, Tracy; Baselga, José; N. Louis, David; Getz, Gad; C. Hahn, William

doi:10.1158/2159-8290.cd-15-0369

Public

Genomic Characterization of Brain Metastases Reveals Branched Evolution and Potential Therapeutic Targets

Published in Cancer Discovery • Sep 26, 2015

Authors:

Priscilla K. Brastianos

Scott L. Carter

Sandro Santagata

Abstract

UNLABELLED: Brain metastases are associated with a dismal prognosis. Whether brain metastases harbor distinct genetic alterations beyond those observed in primary tumors is unknown. We performed whole-exome sequencing of 86 matched brain metastases, primary tumors, and normal tissue. In all clonally...

Subject

Primary tumor

Brain metastasis

Exome sequencing

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