Modelling kidney disease with CRISPR-mutant kidney organoids derived from human pluripotent epiblast spheroids

Freedman, Benjamin; R. Brooks, Craig; Q. Lam, Albert; Fu, Hongxia; Morizane, Ryuji; Agrawal, Vishesh; F. Saad, Abdelaziz; K. Li, Michelle; R. Hughes, Michael; Vander Werff, Ryan; Peters, Derek; Lu, Junjie; Baccei, Anna; M. Siedlecki, Andrew; Todd Valerius, M.; Musunuru, Kiran; M. McNagny, Kelly; I. Steinman, Theodore; Zhou, Jing; H. Lerou, Paul; V. Bonventre, Joseph

doi:10.1038/ncomms9715

Public

Modelling kidney disease with CRISPR-mutant kidney organoids derived from human pluripotent epiblast spheroids

Published in Nature Communications • Oct 23, 2015

Authors:

Benjamin Freedman

Craig R. Brooks

Albert Q. Lam

Abstract

Human-pluripotent-stem-cell-derived kidney cells (hPSC-KCs) have important potential for disease modelling and regeneration. Whether the hPSC-KCs can reconstitute tissue-specific phenotypes is currently unknown. Here we show that hPSC-KCs self-organize into kidney organoids that functionally recapit...

Subject

Induced pluripotent stem cell

Cell biology

Biology

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