Chemo-enzymatic Synthesis of 3-Deoxy-β-<scp>D</scp>-ribofuranosyl Purines and Study of Their Biological Properties

N. Barai, V.; И. Зинченко, А.; A. Eroshevskaya, L.; V. Zhernosek, Elena; Balzarini, Jan; De Clercq, Erik; A. Mikhailopulo, Igor

doi:10.1081/ncn-120022626

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Chemo-enzymatic Synthesis of 3-Deoxy-β-D-ribofuranosyl Purines and Study of Their Biological Properties

Published in Nucleosides Nucleotides & Nucleic Acids • Sep 16, 2003

Authors:

V. N. Barai

А. И. Зинченко

L. A. Eroshevskaya

Abstract

9-(3-Deoxy-beta-D-erythro-pentofuranosyl)-2,6-diaminopurine (2) was synthesized by an enzymatic transglycosylation of 2,6-diaminopurine using 3'-deoxycytidine (1) as a donor of the sugar moiety. Nucleoside 2 was transformed to 3'-deoxy guanosine (3), 9-(3-deoxy-beta-D-erythro-pentofuranosyl)-2-amino...

Subject

Chemistry

Guanosine

Nucleoside

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