Designing a broad-spectrum integrative approach for cancer prevention and treatment

I. Block, Keith; Gyllenhaal, Charlotte; Lowe, Leroy; Amedei, Amedeo; Ruhul Amin, A.R.M.; Amin, Amr; Aquilano, Katia; L. Arbiser, Jack; Arreola, Alexandra; Arzumanyan, Alla; M. Ashraf, S.; S. Azmi, Asfar; Benencia, Fabián; Bhakta-Guha, Dipita; Bilsland, Alan; Bishayee, Anupam; W. Blain, Stacy; B. Block, Penny; S. Boosani, Chandra; E. Carey, Thomas; Carnero, Amancio; Carotenuto, Marianeve; C. Casey, Stephanie; Chakrabarti, Mrinmay; Chaturvedi, Rupesh; Zhuo Chen, Georgia; Chen, Helen; Chen, Sophie; Chen, Yi; K. Choi, Beom; Rosa Ciriolo, Maria; M. Coley, Helen; Collins, Andrew; Connell, Marisa; Crawford, Sarah; S. Curran, Colleen; Dabrosin, Charlotta; Damia, Giovanna; Dasgupta, Santanu; J. DeBerardinis, Ralph; K. Decker, William; Dhawan, Punita; Mae Diehl, Anna; Dong, Jin‐Tang; Ping Dou, Q.; E. Drew, Janice; Elkord, Eyad; F. El‐Rayes, Bassel; A. Feitelson, Mark; W. Felsher, Dean; R. Ferguson, Lynnette; Fimognari, Carmela; L. Firestone, Gary; Frezza, Christian; Fujii, Hiromasa; M. Fuster, Mark; Generali, Daniele; G. Georgakilas, Alexandros; Gieseler, Frank; Gilbertson, Michael; Green, Michelle; Grue, Brendan; Guha, Gunjan; Halicka, Dorota; G. Helferich, William; Heneberg, Petr; Hentosh, Patricia; D. Hirschey, Matthew; J. Hofseth, Lorne; F. Holcombe, Randall; Honoki, Kanya; Hsu, Hsue-Yin; S. Huang, Gloria; D. Jensen, Lasse; G. Jiang, Wen; W. Jones, Lee; Karpowicz, Phillip; Nicol Keith, W.; P. Kerkar, Sid; Khan, Gazala; Khatami, Mahin; Hee Ko, Young; Küçük, Ömer; J. Kulathinal, Rob; B. Kumar, Nagi; S. Kwon, Byoung; Le, Anne; A. Lea, Michael; Lee, Ho‐Young; Lichtor, Terry; Lin, Liang; W. Locasale, Jason; L. Lokeshwar, Bal; D. Longo, Valter; A. Lyssiotis, Costas; L. MacKenzie, Karen; Malhotra, Meenakshi; Marino, Maria; Luz Martínez‐Chantar, Maria; Matheu, Ander; A. Maxwell, Christopher; McDonnell, Eoin; K. Meeker, Alan; Mehrmohamadi, Mahya; Mehta, Kapil; Michelotti, Gregory; M. Mohammad, Ramzi; I. Mohammed, Sulma; James Morré, D.; Muralidhar, Vinayak; Muqbil, Irfana; P. Murphy, Michael; Purnachandra Nagaraju, Ganji; Nahta, Rita; Niccolai, Elena; Nowsheen, Somaira; Panis, Carolina; Pantano, Francesco; R. Parslow, Virginia; Pawelec, Graham; L. Pedersen, Peter; Poore, Brad; Poudyal, Deepak; Prakash, Satya; E. Prince, Mark; Raffaghello, Lizzia; C. Rathmell, Jeffrey; Kimryn Rathmell, W.; K. Ray, Swapan; Reichrath, Jörg; Rezazadeh, Sarallah; Ribatti, Doménico; Ricciardiello, Luigi; Brooks Robey, R.; Rodier, Françis; Vasantha Rupasinghe, H.P.; Luigi Russo, Gian; P. Ryan, Elizabeth; Samadi, Abbas; Sánchez-Garcı́a, Isidro; J. Sanders, Andrew; Santini, Daniele; Sarkar, Malancha; Sasada, Tetsuro; K. Saxena, Neeraj; E. Shackelford, Rodney; M. C. Shantha Kumara, H.; Sharma, Dipali; M. Shin, Dong; Sidransky, David; D. Siegelin, Markus; Signori, Emanuela; Singh, Neetu; Sivanand, Sharanya; Slíva, Daniel; Smythe, Carl; Spagnuolo, Carmela; M. Stafforini, Diana; Stagg, John; R. Subbarayan, Pochi; Sundin, Tabetha; H. Talib, Wamidh; K. Thompson, Sarah; T. Tran, Phuoc; Ungefroren, Hendrik; G. Vander Heiden, Matthew; Venkateswaran, Vasundara; S. Vinay, Dass; J. Vlachostergios, Panagiotis; Wang, Zongwei; E. Wellen, Kathryn; L. Whelan, Richard; S. Yang, Eddy; Yang, Huanjie; Yang, Xujuan; Yaswen, Paul; G. Yedjou, Clément; Yin, Xin; Zhu, Jiyue; Zollo, Massimo

doi:10.1016/j.semcancer.2015.09.007

Public

Designing a broad-spectrum integrative approach for cancer prevention and treatment

Published in Seminars in Cancer Biology • Nov 18, 2015

Authors:

Keith I. Block

Charlotte Gyllenhaal

Leroy Lowe

Abstract

Targeted therapies and the consequent adoption of "personalized" oncology have achieved notable successes in some cancers; however, significant problems remain with this approach. Many targeted therapies are highly toxic, costs are extremely high, and most patients experience relapse after a few dis...

Subject

Broad spectrum

Tumor microenvironment

Cancer

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