Germline Mutations in <i>HOXB13</i> and Prostate-Cancer Risk

M. Ewing, Charles; M. Ray, Anna; M. Lange, Ethan; A. Zuhlke, Kimberly; M. Robbins, Christiane; Tembe, Waibhav; E. Wiley, Kathleen; D. Isaacs, Sarah; Johng, Dorhyun; Wang, Yunfei; Bizon, Chris; Yan, Guifang; Gielzak, Marta; W. Partin, Alan; Shanmugam, Vijayalakshmi; Izatt, Tyler; Sinari, Shripad; W. Craig, David; Zheng, Shusen; C. Walsh, Patrick; E. Montie, James; Xu, Jianfeng; D. Carpten, John; B. Isaacs, William; A. Cooney, Kathleen

doi:10.1056/nejmoa1110000

Public

Germline Mutations in HOXB13 and Prostate-Cancer Risk

Published in New England Journal of Medicine • Jan 11, 2012

Authors:

Charles M. Ewing

Anna M. Ray

Ethan M. Lange

Abstract

BACKGROUND: Family history is a significant risk factor for prostate cancer, although the molecular basis for this association is poorly understood. Linkage studies have implicated chromosome 17q21-22 as a possible location of a prostate-cancer susceptibility gene. METHODS: We screened more than 200...

Subject

Prostate cancer

Medicine

Germline mutation

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