Prevention of conversion to abnormal transcranial <scp>D</scp>oppler with hydroxyurea in sickle cell anemia: A <scp>P</scp>hase III international randomized clinical trial

S. Hankins, Jane; Beth McCarville, Mary; Rankine‐Mullings, Angela; Reid, Marvin; L. C. Lobo, Clarisse; Moura, Patrícia; Bortolusso Ali, Susanna; Soares, Deanne; Aldred, Karen; W. Jay, Dennis; Aygün, Banu; M. Bennett, John; Kang, Guolian; C. Goldsmith, Jonathan; P. Smeltzer, Matthew; M. Boyett, James; E. Ware, Russell

doi:10.1002/ajh.24198

Public

Prevention of conversion to abnormal transcranial Doppler with hydroxyurea in sickle cell anemia: A Phase III international randomized clinical trial

Published in American Journal of Hematology • Sep 28, 2015

Authors:

Jane S. Hankins

Mary Beth McCarville

Angela Rankine‐Mullings

Abstract

Children with sickle cell anemia (SCA) and conditional transcranial Doppler (TCD) ultrasound velocities (170-199 cm/sec) may develop stroke. However, with limited available clinical data, the current standard of care for conditional TCD velocities is observation. The efficacy of hydroxyurea in preve...

Subject

Transcranial Doppler

Medicine

Sickle cell anemia

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