<i>HLA-DRB1*11</i> and variants of the MHC class II locus are strong risk factors for systemic juvenile idiopathic arthritis

J. Ombrello, Michael; F. Remmers, Elaine; Tachmazidou, Ioanna; A. Grom, Alexei; Foell, Dirk; Haas, Johannes‐Peter; Martini, Alberto; Gattorno, Marco; Özen, Seza; Prahalad, Sampath; Zeft, Andrew; F. Bohnsack, John; Mellins, Elizabeth; T. Ilowite, Norman; Russo, Ricardo; Arnaldo Len, Cláudio; Odete Esteves Hilário, Maria; Oliveira, Sheila; S. M. Yeung, Rae; Rosenberg, Alan; R. Wedderburn, Lucy; Antón, Jordi; Schwarz, Tobias; Hinks, Anne; Bilginer, Yelda; Park, Jane; Cobb, Joanna; Satorius, Colleen; Han, Buhm; Baskin, Elizabeth; Signa, Sara; H. Duerr, Richard; ACHKAR, J; Ilyas Kamboh, M.; M. Kaufman, Kenneth; C. Kottyan, Leah; Pinto, Dalila; W. Scherer, Stephen; E. Alarcón‐Riquelme, Marta; Docampo, Elisa; Estivill, Xavier; Gül, Ahmet; Society of Pediatric and Adolescent Rheumatology (BSPAR) Study Group, British; Arthritis Prospective Study (CAPS) Group, Childhood; Placebo Phase Study of Rilonacept in sJIA (RAPPORT) Investigators, Randomized; Arthritis Response to Medication Study (CHARMS) Group, Sparks-Childhood; Based Outcome Predictors in JIA (BBOP) Group, Biologically; I. W. de Bakker, Paul; Raychaudhuri, Soumya; D. Langefeld, Carl; Thompson, Susan; Zeggini, Eleftheria; Thomson, Wendy; L. Kastner, Daniel; Woo, Patricia; ACHKAR, J; E. Alarcón‐Riquelme, Marta; C. Allen, Roger; Antón, Jordi; Baskin, Elizabeth; Berg, Stefan; Bica, Bianca; Bilginer, Yelda; F. Bohnsack, John; Cavalcanti, André; Chaitow, Jeffrey; Cobb, Joanna; Cuttica, Rubin; I. W. de Bakker, Paul; Docampo, Elisa; H. Duerr, Richard; A. Ellis, Justine; Estivill, Xavier; H. Finkel, Terri; Foell, Dirk; Gattorno, Marco; A. Grom, Alexei; Gül, Ahmet; Haas, Johannes‐Peter; Håkonarson, Håkon; Han, Buhm; Odete Esteves Hilário, Maria; Hinks, Anne; T. Ilowite, Norman; Ilyas Kamboh, M.; L. Kastner, Daniel; M. Kaufman, Kenneth; C. Kottyan, Leah; Langefeld, Carl; Arnaldo Len, Cláudio; Martini, Alberto; Mellins, Elizabeth; Minden, Kirstin; Murray, Kevin; Oliveira, Sheila; J. Ombrello, Michael; Özen, Seza; Park, Jane; Pinto, Dalila; Prahalad, Sampath; Quartier, Pierre; Raychaudhuri, Soumya; F. Remmers, Elaine; Rosenberg, Alan; Russo, Ricardo; Satorius, Colleen; W. Scherer, Stephen; Schneider, Rayfel; Schwarz, Tobias; Singh-Gerwal, Davinder; Tachmazidou, Ioanna; Thompson, Susan; Thomson, Wendy; R. Wedderburn, Lucy; Woo, Patricia; Wulffraat, Nico; SM Yeung, Rae; Zeft, Andrew; Zeggini, Eleftheria; Abinum, Mario; L. Bell, A.; Craft, Alan; Crawley, Esther; David, Joel; Foster, Helen; Gardener-Medwin, Janet; Griffin, Jane; Hall, Ann; E. Hall, Michael; L. Herrick, Ariane; Hollingworth, P.; Holt, Lennox; Jones, Stan; Pountain, G.; Ryder, Clive; Southwood, Tauny; M Stewart, I; Venning, H; R. Wedderburn, Lucy; Woo, Patricia; Wyatt, Sue; Baildam, Eileen; Bishop, Nick; Brown, Lynsey; Buckley, Joanne; Chieng, Alice; Carrasco, Roberto; Cobb, Joanna; Cook, Lucy; Davidson, Joyce; Duggan, Annette; Eltringham, Michael; Foster, Helen; Friel, Elizabeth; Friswell, Mark; Gardner‐Medwin, Janet; Gilbert, Paul; C. Gould, V.; Hadfield, Kelly; L Hyrich, Kimme; E. Jones, J.; Lal, Sham; J. Lay, M.-L.; Lloyd, Gabrielle; Lloyd, Olivia; Lydon, Carol; Makengo, N; McGovern, Ann; Meijer, Alexandra; Mills-Wierda, Nicola; Moorcroft, Theresa; Price, Vicki; Qiao, Liang; Riding, Kay; Sim, Jane; Southwood, Tauny; Thomson, Wendy; Todd, Maureen; Tremble, Susan; Venter, Katharine; Wade, Debbie; Ward, Peter; Watson, Sharon; Webster, Gwen; R. Wedderburn, Lucy; Zelenovic, Jadranka; Birmingham, James; E. Elder, Melissa; S. Gottlieb, Beth; T. Ilowite, Normal; F. Imundo, Lisa; Kimura, Yukiko; Lokhnygina, Yuliya; L. Miller, Michael; Milojevic, Diana; M. O’Neil, Kathleen; Punaro, Marilynn; Prather, Kristi; M. Ruth, Natasha; Sandborg, Christy; E. Schanberg, Laura; D. Sherry, David; G. Singer, Nora; J. Spalding, Steven; E. Tarvin, Stacey; Verbsky, James; A. Wallace, Carol; Zemel, Lawrence; Burkle, Katrin; Cobb, Joanna; Etheridge, Angela; Gilbert, Paul; Hinks, Anne; P. Hirani, Shashivadan; Kassoumeri, Laura; Lal, Sham; Melville, Laura; Moncrieffe, Halima; Mulligan, Kathleen; Newman, Stanton; Patrick, Fiona; Southwood, Tauny; Thomson, Wendy; Ursu, Simona; R. Wedderburn, Lucy; Whitworth, Pamela; Woo, Patricia; Baxter‐Jones, Adam; M. Benseler, Susanne; Boire, Gilles; A. Cabral, David; Cameron, Bonnie; Campillo, Sarah; Chédeville, Gaëlle; Chetaille, Anne-Laure; Dancey, Paul; M. Duffy, Ciarán; Watanabe Duffy, Karen; Ellsworth, Janet; M. Feldman, Brian; Gibbon, Michele; Guillet, Chantal; Guzmán, Jaime; Houghton, Kristin; M. Huber, Adam; Juřenčák, Roman; Lang, Bianca; M. Laxer, Ronald; Maenz, Lynn; A. Matheson, Loren; Oen, Kiem; E. Petty, Ross; Ramsey, Suzanne; Rezaei, Elham; Rosenberg, Alan; Roth, Johannes; Schneider, Rayfel; Scuccimarri, Rosie; D. Silverman, Earl; Spiegel, Lynn; Stringer, Elizabeth; M. L. Tse, Shirley; B. Tucker, Lori; E. Turvey, Stuart; SM Yeung, Rae

doi:10.1073/pnas.1520779112

Public

HLA-DRB1*11 and variants of the MHC class II locus are strong risk factors for systemic juvenile idiopathic arthritis

Published in Proceedings of the National Academy of Sciences • Nov 23, 2015

Authors:

Michael J. Ombrello

Elaine F. Remmers

Ioanna Tachmazidou

Abstract

Systemic juvenile idiopathic arthritis (sJIA) is an often severe, potentially life-threatening childhood inflammatory disease, the pathophysiology of which is poorly understood. To determine whether genetic variation within the MHC locus on chromosome 6 influences sJIA susceptibility, we performed a...

Subject

Single-nucleotide polymorphism

Locus (genetics)

Haplotype

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