Dual Roles of RNF2 in Melanoma Progression

Rai, Kunal; C. Akdemir, Kadir; N. Kwong, Lawrence; Fiziev, Petko; Wu, Chang‐Jiun; Z. Keung, Emily; Sharma, Sneha; S. Samant, Neha; Williams, Maura; B. Axelrad, Jacob; Shah, Amiksha; Yang, Dong; A. Grimm, Elizabeth; Barton, Michelle; R. Milton, Denái; P. Heffernan, Timothy; W. Horner, James; Ekmekçioglu, Sühendan; J. Lazar, Alexander; Ernst, Jason; Chin, Lynda

doi:10.1158/2159-8290.cd-15-0493

Public

Dual Roles of RNF2 in Melanoma Progression

Published in Cancer Discovery • Oct 8, 2015

Authors:

Kunal Rai

Kadir C. Akdemir

Lawrence N. Kwong

Abstract

UNLABELLED: Epigenetic regulators have emerged as critical factors governing the biology of cancer. Here, in the context of melanoma, we show that RNF2 is prognostic, exhibiting progression-correlated expression in human melanocytic neoplasms. Through a series of complementary gain-of-function and l...

Subject

Epigenetics

Biology

Cancer research

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