The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study

W. Winkler, Thomas; E. Justice, Anne; Graff, Mariaelisa; Barata, Llilda; F. Feitosa, Mary; H. Chu, Su; Czajkowski, Jacek; Esko, Tõnu; Fall, Tove; O. Kilpeläinen, Tuomas; Lu, Yingchang; Mägi, Reedik; Mihailov, Evelin; H. Pers, Tune; Rüeger, Sina; Teumer, Alexander; Ehret, Georg; Ferreira, Teresa; L. Heard‐Costa, Nancy; Karjalainen, Juha; Lagou, Vasiliki; Mahajan, Anubha; D. Neinast, Michael; Prokopenko, Inga; Simino, Jeannette; M. Teslovich, Tanya; Jansen, Rick; Westra, Harm-Jan; C. White, Charles; Absher, Devin; S. Ahluwalia, Tarunveer; Ahmad, Shafqat; Albrecht, Eva; Couto Alves, Alexessander; L. Bragg‐Gresham, Jennifer; J. M. de Craen, Anton; C. Bis, Joshua; Bonnefond, Amélie; Boucher, Gabrielle; Cadby, Gemma; Cheng, Yu‐Ching; W. K. Chiang, Charleston; Delgado, Graciela; Demirkan, Ayşe; Dueker, Nicole; Eklund, Niina; Eiríksdóttir, Guðný; Eriksson, Joel; Feenstra, Bjarke; Fischer, Krista; Frau, Francesca; E. Galesloot, Tessel; Geller, Frank; Goel, Anuj; Gorski, Mathias; B. Grammer, Tanja; Gustafsson, Stefan; Haitjema, Saskia; Hottenga, Jouke‐Jan; E. Huffman, Jennifer; Jackson, Anne; B. Jacobs, Kevin; Johansson, Åsa; Kaakinen, Marika; E. Kleber, Marcus; Lahti, Jari; Mateo Leach, Irene; Lehne, Benjamin; Liu, Youfang; Sin Lo, Ken; Lorentzon, Mattias; Luan, Jian’an; A. F. Madden, Pamela; Mangino, Massimo; McKnight, Barbara; Medina‐Gómez, Carolina; L. Monda, Keri; E. Montasser, May; Müller, Gabriele; Müller‐Nurasyid, Martina; M. Nolte, Ilja; Panoutsopoulou, Kalliope; Pascoe, Laura; Paternoster, Lavinia; W. Rayner, Nigel; Renström, Frida; Rizzi, Federica; M. Rose, Lynda; A. Ryan, Kathy; Salo, Perttu; Sanna, Serena; Scharnagl, Hubert; Shi, Jianxin; V. Smith, Albert; Southam, Lorraine; Stančáková, Alena; Steinthórsdóttir, Valgerður; J. Strawbridge, Rona; Ju Sung, Yun; Tachmazidou, Ioanna; Tanaka, Toshiko; Þorleifsson, Guðmar; Trompet, Stella; Pervjakova, Natalia; P. Tyrer, Jonathan; Vandenput, Liesbeth; W. van der Laan, Sander; van der Velde, Nathalie; van Setten, Jessica; V. van Vliet‐Ostaptchouk, Jana; Verweij, Niek; Vlachopoulou, Efthymia; L. Waite, Lindsay; R. Wang, Sophie; Wang, Zhaoming; H. Wild, Sarah; Willenborg, Christina; F. Wilson, James; Wong, Andrew; Yang, Jian; Yengo, Loïc; M. Yerges-Armstrong, Laura; Yu, Lei; Zhang, Weihua; Zhao, Wei; A. Andersson, Ehm; J. L. Bakker, Stephan; Baldassarre, Damiano; Banasik, Karina; Barcella, Matteo; Barlassina, Cristina; Bellis, Claire; Benaglio, Paola; Blangero, John; Blüher, Matthias; Bonnet, Fabrice; L. Bonnycastle, Lori; A. Boyd, Heather; Bruinenberg, Marcel; S. Buchman, Aron; Campbell, Harry; Ida Chen, Yii‐Der; S. Chines, Peter; Claudi-Boehm, Simone; W. Cole, John; S. Collins, Francis; J. C. de Geus, Eco; de Groot, C.P.G.M.; Dimitriou, Maria; Duan, Jubao; Enroth, Stefan; Eury, Elodie; Farmaki, Aliki‐Eleni; G. Forouhi, Nita; Friedrich, Nele; V. Gejman, Pablo; Gigante, Bruna; Glorioso, Nicola; S. Go, Alan; Gottesman, Omri; Gräßler, Jürgen; Grallert, Harald; Grarup, Niels; Gu, Yumei; Broer, Linda; C. Ham, Annelies; Hansen, Torben; B. Harris, Tamara; A. Hartman, Catharina; Hassinen, Maija; D. Hastie, Nicholas; T. Hattersley, Andrew; C. Heath, Andrew; K. Henders, Anjali; Hernández, Dena; L. Hillege, Hans; L. Holmen, Oddgeir; Hovingh, Kees; Hui, Jennie; Lotte N. Husemoen, Lise; Hutri‐Kähönen, Nina; G. Hysi, Pirro; Illig, Thomas; L. De Jager, Philip; Jalilzadeh, Shapour; Jørgensen, Torben; Wouter Jukema, J.; Juonala, Markus; Kanoni, Stavroula; Karaleftheri, Maria; Khaw, Kay‐Tee; Kinnunen, Leena; J. Kittner, Steven; Köenig, Wolfgang; Kolčić, Ivana; Kovács, Péter; T. Krarup, Nikolaj; Kratzer, Wolfgang; Krüger, Janine; Kuh, Diana; Kumari, Meena; Kyriakou, Theodosios; Langenberg, Claudia; Lannfelt, Lars; Lanzani, Chiara; Lotay, Vaneet; J. Launer, Lenore; Leander, Karin; Lindström, Jaana; Linneberg, Allan; Liu, Yanping; Lobbens, Stéphane; Luben, Robert; Lyssenko, Valeriya; Männistö, Satu; K. E. Magnusson, Patrik; L. McArdle, Wendy; Menni, Cristina; Merger, Sigrun; Milani, Lili; W. Montgomery, Grant; P. Morris, Andrew; Narisu, Narisu; Nelis, Mari; K. Ong, Ken; Palotie, Aarno; Përusse, Louis; Pichler, Irene; Grazia Pilia, Maria; Pouta, Anneli; Rheinberger, Myriam; Ribel‐Madsen, Rasmus; Richards, Marcus; Rice, Kenneth; Rice, Treva; Rivolta, Carlo; Salomaa, Veikko; R. Sanders, Alan; A. Sarzynski, Mark; Scholtens, Salome; A. Scott, Robert; R. Scott, William; Sebért, Sylvain; Sengupta, Sebanti; Sennblad, Bengt; Seufferlein, Thomas; Silveira, Angela; Eline Slagboom, P.; Smit, Jan; Sparsø, Thomas; Stirrups, Kathleen; P. Stolk, Ronald; M. Stringham, Heather; A. Swertz, Morris; J. Swift, Amy; Syvänen, Ann‐Christine; Tan, Sian-Tsung; Thorand, Barbara; Tönjes, Anke; Tremblay, Angelo; Tsafantakis, Emmanouil; J. van der Most, Peter; Völker, Uwe; Vohl, Marie‐Claude; M. Vonk, Judith; Waldenberger, Mélanie; W. Walker, Ryan; Wennauer, Roman; Widén, Elisabeth; Willemsen, Gonneke; Wilsgaard, Tom; F. Wright, Alan; Carola Zillikens, M.; C. van Dijk, Suzanne; M. van Schoor, Natasja; W. Asselbergs, Folkert; I. W. de Bakker, Paul; Beckmann, J.; Beilby, John; A. Bennett, David; N. Bergman, Richard; Bergmann, Sven; A. Böger, Carsten; O. Boehm, Bernhard; Boerwinkle, Eric; I. Boomsma, Dorret; R. Bornstein, Stefan; P. Böttinger, Erwin; Bouchard, Claude; C. Chambers, John; J. Chanock, Stephen; I. Chasman, Daniel; Cucca, Francesco; Cusi, Daniele; Dedoussis, George; Erdmann, Jeanette; G. Eriksson, Johan; A. Evans, Denis; dé Fairé, Ulf; Farrall, Martin; Ferrucci, Luigi; Ford, Ian; Franke, Lude; W. Franks, Paul; Froguel, Philippe; T. Gansevoort, Ron; Gieger, Christian; Grönberg, Henrik; Guðnason, Vilmundur; Gyllensten, Ulf; Hall, Per; Hamsten, Anders; van der Harst, Pim; Hayward, Caroline; Heliövaara, Markku; Hengstenberg, Christian; A. Hicks, Andrew; D. Hingorani, Aroon; Hofman, Albert; B. Hu, Frank; V. Huikuri, Heikki; Hveem, Kristian; L. James, Alan; M. Jordan, Joanne; Jula, Antti; Kähönen, Mika; Kajantie, Eero; Kathiresan, Sekar; A. Kiemeney, Lambertus; Kivimäki, Mika; Knekt, Paul; A. Koistinen, Heikki; S. Kooner, Jaspal; Koskinen, Seppo; Kuusisto, Johanna; Maerz, Winfried; G. Martin, Nicholas; Laakso, Markku; A. Lakka, Timo; Lehtimäki, Terho; Lettre, Guillaume; F. Levinson, Douglas; Lind, Lars; Lokki, Marja‐Liisa; Mäntyselkä, Pekka; Melbye, Mads; Metspalu, Andres; D. Mitchell, Braxton; L. Moll, Frans; C. Murray, Jeffrey; W. Musk, Arthur; S. Nieminen, Markku; Njølstad, Inger; Ohlsson, Claes; J. Oldehinkel, Albertine; A. Oostra, Ben; J. Palmer, Lyle; S. Pankow, James; Pasterkamp, Gerard; L. Pedersen, Nancy; Pedersen, Oluf; W.J.H. Penninx, Brenda; Perola, Markus; Peters, Annette; Polašek, Ozren; P. Pramstaller, Peter; M. Psaty, Bruce; Qi, Lu; Quertermous, Thomas; T. Raitakari, Olli; Rankinen, Tuomo; Rauramaa, Rainer; M. Ridker, Paul; D. Rioux, John; Rivadeneira, Fernando; I. Rotter, Jerome; Rudan, Igor; M. den Ruijter, Hester; Saltevo, Juha; Sattar, Naveed; Schunkert, Heribert; Schwarz, Peter; R. Shuldiner, Alan; Sinisalo, Juha; Snieder, Harold; I. A. Sørensen, Thorkild; D. Spector, Tim; A. Staessen, Jan; Stefania, Bandinelli; Þorsteinsdóttir, Unnur; Stümvoll, Michael; Tardif, Jean‐Claude; Tremoli, Elena; Tuomilehto, Jaakko; G. Uitterlinden, André; Uusitupa, Matti; L. M. Verbeek, André; H. Vermeulen, Sita; Viikari, Jorma; Vitart, Véronique; Völzke, Henry; Vollenweider, Péter; Waeber, Gérard; Walker, Mark; Wallaschofski, Henri; J. Wareham, Nicholas; Watkins, Hugh; Zeggini, Eleftheria; Chakravarti, Aravinda; J. Clegg, Deborah; Adrienne Cupples, L.; Gordon‐Larsen, Penny; E. Jaquish, Cashell; C. Rao, D.; R. Abecasis, Gonçalo; L. Assimes, Themistocles; Barroso, Inês; I. Berndt, Sonja; Boehnke, Michael; Deloukas, Panos; S. Fox, Caroline; Groop, Leif; J. Hunter, David; Ingelsson, Erik; C. Kaplan, Robert; I. McCarthy, Mark; L. Mohlke, Karen; R. O’Connell, Jeffrey; Schlessinger, David; P. Strachan, David; Stefánsson, Kāri; M. van Duijn, Cornelia; N. Hirschhorn, Joel; M. Lindgren, Cecilia; M. Heid, Iris; E. North, Kari; B. Borecki, Ingrid; Kutalik, Zoltán; J. F. Loos, Ruth

doi:10.1371/journal.pgen.1005378

Public

The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study

Published in PLoS Genetics • Oct 1, 2015

Authors:

Thomas W. Winkler

Anne E. Justice

Mariaelisa Graff

Abstract

Genome-wide association studies (GWAS) have identified more than 100 genetic variants contributing to BMI, a measure of body size, or waist-to-hip ratio (adjusted for BMI, WHRadjBMI), a measure of body shape. Body size and shape change as people grow older and these changes differ substantially betw...

Subject

Genome-wide association study

Anthropometry

Biology

Research Assistant

AI chat, annotations, notes & similar papers

Finding related papers...

Discussions

(0)

No comments yet

Be the first to share your thoughts!