Minimum Information about a Biosynthetic Gene cluster

H. Medema, Marnix; Kottmann, Renzo; Yilmaz, Pelin; Cummings, Matthew; Biggins, John; Blin, Kai; de Bruijn, Irene; Chooi, Yit‐Heng; Claesen, Jan; Coates, Roger; Cruz‐Morales, Pablo; Duddela, Srikanth; Düsterhus, Stephanie; Edwards, Daniel; P. Fewer, David; Garg, Neha; Geiger, Christoph; Pablo Gomez‐Escribano, Juan; Greule, Anja; Hadjithomas, Michalis; S. Haines, Anthony; J. N. Helfrich, Eric; L. Hillwig, Matthew; Ishida, Keishi; C. Jones, Adam; S. Jones, Carla; Jungmann, Katrin; Kegler, Carsten; Uk Kim, Hyun; Kötter, Peter; Krug, Daniel; Masschelein, Joleen; V. Melnik, Alexey; M. Mantovani, Simone; A. Monroe, Emily; A. Moore, Marcus; A. Moss, Nathan; Nützmann, Hans‐Wilhelm; Pan, Guohui; Pati, Amrita; Petras, Daniel; Jerry Reen, F.; Rosconi, Federico; Rui, Zhe; Tian, Zhenhua; J. Tobias, Nicholas; Tsunematsu, Yuta; Wiemann, Philipp; E. Wyckoff, Elizabeth; Yan, Xiaohui; Yim, Grace; Yu, Fengan; Xie, Yunchang; Aigle, Bertrand; K. Apel, Alexander; J. Balibar, Carl; P. Balskus, Emily; Barona‐Gómez, Francisco; Bechthold, Andreas; B. Bode, Helge; Borriss, Rainer; F. Brady, Sean; A. Brakhage, Axel; Caffrey, Patrick; Cheng, Yi‐Qiang; Clardy, Jon; J. Cox, Russell; De Mot, René; Donadio, Stefano; S. Donia, Mohamed; A. van der Donk, Wilfred; C. Dorrestein, Pieter; Doyle, Seán; J. M. Driessen, Arnold; Ehling‐Schulz, Monika; Entian, Karl-Dieter; A. Fischbach, Michael; Gerwick, Lena; H. Gerwick, William; Gross, Harald; Gust, Bertolt; Hertweck, Christian; Höfte, Monica; E. Jensen, Susan; Ju, Jianhua; Katz, Leonard; Kaysser, Leonard; L. Klassen, Jonathan; P. Keller, Nancy; Kormanec, Ján; P. Kuipers, Oscar; Kuzuyama, Tomohisa; C. Kyrpides, Nikos; Kwon, Hyung-Jin; Lautru, Sylvie; Lavigne, Rob; Y. Lee, Chia; Bai, Linquan; Liu, Xinyu; Liu, Wen; Luzhetskyy, Andriy; Mahmud, Taifo; Mast, Yvonne; Méndez, Cármen; Metsä‐Ketelä, Mikko; Micklefield, Jason; A. Mitchell, Douglas; S Moore, Bradley; M. Moreira, Leonilde; Müller, Rolf; A. Neilan, Brett; Nett, Markus; Nielsen, Jens; O’Gara, Fergal; Oikawa, Hideaki; Osbourn, Anne; S. Osburne, Marcia; Ostash, Bohdan; M. Payne, Shelley; Pernodet, Jean‐Luc; Petřı́ček, Miroslav; Piel, Jörn; Ploux, Olivier; M. Raaijmakers, Jos; A. Salas, José; Schmitt, E.; Scott, Barry; F. Seipke, Ryan; Shen, Ben; H. Sherman, David; Sivonen, Kaarina; J. Smanski, Michael; Sosio, Margherita; Stegmann, Evi; D. Süßmuth, Roderich; Tahlan, Kapil; M. Thomas, Christopher; Tang, Yi; W. Truman, Andrew; Viaud, Muriel; D. Walton, Jonathan; T. Walsh, Christopher; Weber, Tilmann; P. van Wezel, Gilles; Wilkinson, Barrie; M. Willey, Joanne; Wohlleben, Wolfgang; D. Wright, Gerard; Ziemert, Nadine; Zhang, Changsheng; B. Zotchev, Sergey; Breitling, Rainer; Takano, Eriko; Oliver Glöckner, Frank

doi:10.1038/nchembio.1890

Public

Minimum Information about a Biosynthetic Gene cluster

Published in Nature Chemical Biology • Aug 18, 2015

Authors:

Marnix H. Medema

Renzo Kottmann

Pelin Yilmaz

Abstract

A wide variety of enzymatic pathways that produce specialized metabolites in bacteria, fungi and plants are known to be encoded in biosynthetic gene clusters. Information about these clusters, pathways and metabolites is currently dispersed throughout the literature, making it difficult to exploit. ...

Subject

Gene cluster

Gene

Computational biology

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