Sixteen new lung function signals identified through 1000 Genomes Project reference panel imputation

Soler Artigas, María; V. Wain, Louise; Miller, S.; Kader Kheirallah, Abdul; E. Huffman, Jennifer; Ντάλλα, Ιωάννα; Shrine, Nick; Obeidat, Ma’en; Trochet, Holly; L. McArdle, Wendy; Couto Alves, Alexessander; Hui, Jennie; Zhao, Wei; K. Joshi, Peter; Teumer, Alexander; Albrecht, Eva; Imboden, Medea; Rawal, Rajesh; M. Lopez, Lorna; Marten, Jonathan; Enroth, Stefan; Surakka, Ida; Polašek, Ozren; Lyytikäinen, Leo‐Pekka; Granell, Raquel; G. Hysi, Pirro; Flexeder, Claudia; Mahajan, Anubha; Beilby, John; Bossé, Yohan; Brandsma, Corry‐Anke; Campbell, Harry; Gieger, Christian; Gläser, Sven; R. González, Juan; Grallert, Harald; J. Hammond, Christopher; E. Harris, Sarah; Hartikainen, Anna‐Liisa; Heliövaara, Markku; Henderson, John; J. Hocking, Lynne; Horikoshi, Momoko; Hutri‐Kähönen, Nina; Ingelsson, Erik; Johansson, Åsa; P. Kemp, John; Kolčić, Ivana; Kumar, Ashish; Lind, Lars; Melén, Erik; W. Musk, Arthur; Navarro, Pau; C. Nickle, David; Padmanabhan, Sandosh; T. Raitakari, Olli; S. Ried, Janina; Ripatti, Samuli; Schulz, Holger; A. Scott, Robert; D. Sin, Don; M. Starr, John; BiLEVE, UK; Deloukas, Panos; L. Hansell, Anna; Hubbard, Richard; E. Jackson, Victoria; Marchini, Jonathan; Pavord, Ian; C. Thomson, Neil; Zeggini, Eleftheria; Viñuela, Ana; Völzke, Henry; H. Wild, Sarah; F. Wright, Alan; Zemunik, Tatijana; Jarvis, Deborah; D Spector, Tim; M. Evans, David; Lehtimäki, Terho; Vitart, Véronique; Kähönen, Mika; Gyllensten, Ulf; Rudan, Igor; J. Deary, Ian; Karrasch, Stefan; M Probst-Hensch, Nicole; Heinrich, Joachim; Stubbe, Beate; F Wilson, James; J. Wareham, Nicholas; L James, Alan; P Morris, Andrew; Järvelin, Marjo‐Riitta; Hayward, Caroline; Sayers, Ian; P Strachan, David; P. Hall, Ian; D. Tobin, Martin

doi:10.1038/ncomms9658

Public

Sixteen new lung function signals identified through 1000 Genomes Project reference panel imputation

Published in Nature Communications • Dec 4, 2015

Authors:

María Soler Artigas

Louise V. Wain

S. Miller

Abstract

Lung function measures are used in the diagnosis of chronic obstructive pulmonary disease. In 38,199 European ancestry individuals, we studied genome-wide association of forced expiratory volume in 1 s (FEV1), forced vital capacity (FVC) and FEV1/FVC with 1000 Genomes Project (phase 1)-imputed genot...

Subject

Imputation (statistics)

Genome-wide association study

Vital capacity

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