Cancer-Associated Fibroblasts: Their Characteristics and Their Roles in Tumor Growth

Shiga, Kazuyoshi; Hara, Masayasu; Nagasaki, Takaya; Sato, Takafumi; Takahashi, Hiroki; Takeyama, Hiromitsu

doi:10.3390/cancers7040902

Public

Cancer-Associated Fibroblasts: Their Characteristics and Their Roles in Tumor Growth

Published in Cancers • Dec 11, 2015

Authors:

Kazuyoshi Shiga

Masayasu Hara

Takaya Nagasaki

Abstract

Cancer tissues are composed of cancer cells and the surrounding stromal cells (e.g., fibroblasts, vascular endothelial cells, and immune cells), in addition to the extracellular matrix. Most studies investigating carcinogenesis and the progression, invasion, metastasis, and angiogenesis of cancer ha...

Subject

Angiogenesis

Cancer-Associated Fibroblasts

Stromal cell

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