Prospective Validation of a 21-Gene Expression Assay in Breast Cancer

A. Sparano, Joseph; J. Gray, Robert; Makower, Della; I. Pritchard, Kathleen; S. Albain, Kathy; F. Hayes, Daniel; E. Geyer, Charles; Claire Dees, Elizabeth; A. Perez, Edith; A. Olson, John; Zujewski, JoAnne; Lively, Tracy; Badve, Sunil; J. Saphner, Thomas; I. Wagner, Lynne; J. Whelan, Timothy; J. Ellis, Matthew; Paik, Soonmyung; C. Wood, William; M. Ravdin, Peter; Keane, Maccon; Gómez, Henry; S. Reddy, Pavan; F. Goggins, Timothy; A. Mayer, Ingrid; Brufsky, Adam; Toppmeyer, Deborah; Kaklamani, Virginia; N. Atkins, James; L. Berenberg, Jeffrey; W. Sledge, George

doi:10.1056/nejmoa1510764

Public

Prospective Validation of a 21-Gene Expression Assay in Breast Cancer

Published in New England Journal of Medicine • Sep 28, 2015

Authors:

Joseph A. Sparano

Robert J. Gray

Della Makower

Abstract

BACKGROUND: Prior studies with the use of a prospective-retrospective design including archival tumor samples have shown that gene-expression assays provide clinically useful prognostic information. However, a prospectively conducted study in a uniformly treated population provides the highest level...

Subject

Biomarker

Breast cancer

Oncology

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