Asymmetric ring structure of Vps4 required for ESCRT-III disassembly

Caillat, Christophe; Machebœuf, Pauline; Wu, Yuanfei; A. McCarthy, Andrew; Boeri Erba, Elisabetta; Effantin, Grégory; G. Göttlinger, Heinrich; Weissenhorn, Winfríed; Renesto, Patricia

doi:10.1038/ncomms9781

Public

Asymmetric ring structure of Vps4 required for ESCRT-III disassembly

Published in Nature Communications • Dec 3, 2015

Authors:

Christophe Caillat

Pauline Machebœuf

Yuanfei Wu

Abstract

The vacuolar protein sorting 4 AAA-ATPase (Vps4) recycles endosomal sorting complexes required for transport (ESCRT-III) polymers from cellular membranes. Here we present a 3.6-Å X-ray structure of ring-shaped Vps4 from Metallosphera sedula (MsVps4), seen as an asymmetric pseudohexamer. Conserved ke...

Subject

ESCRT

ATP hydrolysis

AAA proteins

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