Breast-Cancer Risk in Families with Mutations in <i>PALB2</i>

C. Antoniou, Antonis; Casadei, Silvia; Heikkinen, Tuomas; Barrowdale, Daniel; Pylkäs, Katri; Roberts, Jonathan; Lee, Andrew; Subramanian, Deepak; De Leeneer, Kim; Fostira, Florentia; Tomiak, Eva; L. Neuhausen, Susan; L. Teo, Zhi; Khan, Sofia; Aittomäki, Kristiina; S. Moilanen, Jukka; Turnbull, Clare; Seal, Sheila; Mannermaa, Arto; Kallioniemi, Anne; J. Lindeman, Geoffrey; S. Buys, Saundra; L. Andrulis, Irene; Radice, Paolo; Tondini, Carlo; Manoukian, Siranoush; E. Toland, Amanda; Miron, Penelope; N. Weitzel, Jeffrey; M. Domchek, Susan; Poppe, Bruce; Claes, Kathleen; Yannoukakos, Drakoulis; Concannon, Patrick; L. Bernstein, Jonine; A. James, Paul; F. Easton, Douglas; E. Goldgar, David; L. Hopper, John; Rahman, Nazneen; Peterlongo, Paolo; Nevanlinna, Heli; King, Mary‐Claire; J. Couch, Fergus; C. Southey, Melissa; Winqvist, Robert; D. Foulkes, William; Tischkowitz, Marc

doi:10.1056/nejmoa1400382

Public

Breast-Cancer Risk in Families with Mutations in PALB2

Published in New England Journal of Medicine • Aug 6, 2014

Authors:

Antonis C. Antoniou

Silvia Casadei

Tuomas Heikkinen

Abstract

BACKGROUND: Germline loss-of-function mutations in PALB2 are known to confer a predisposition to breast cancer. However, the lifetime risk of breast cancer that is conferred by such mutations remains unknown. METHODS: We analyzed the risk of breast cancer among 362 members of 154 families who had de...

Subject

Breast cancer

PALB2

Medicine

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