IL-25/IL-33–responsive TH2 cells characterize nasal polyps with a default TH17 signature in nasal mucosa

Lam, Emily; H. Kariyawasam, Harsha; M.J. Rana, Batika; R. Durham, Stephen; N. J. McKenzie, Andrew; Powell, Nicholas; Orban, Nara; Lennartz-Walker, Melissa; Hopkins, Claire; Ying, Sun; Rimmer, Joanne; J. Lund, Valerie; J. Cousins, David; J. Till, Stephen

doi:10.1016/j.jaci.2015.10.019

Public

IL-25/IL-33–responsive TH2 cells characterize nasal polyps with a default TH17 signature in nasal mucosa

Published in Journal of Allergy and Clinical Immunology • Dec 15, 2015

Authors:

Emily Lam

Harsha H. Kariyawasam

Batika M.J. Rana

Abstract

BACKGROUND: Chronic rhinosinusitis with nasal polyposis (CRSwNP) in Western countries is characterized by eosinophilia, IgE production, and TH2 cytokine expression. Type 2 innate lymphoid cells from polyps produce IL-5 and IL-13 in response to IL-25 and IL-33, although the relevance of this axis to ...

Subject

Nasal polyps

Immunology

Mucous membrane of nose

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