<i>Fusobacterium nucleatum</i>in colorectal carcinoma tissue and patient prognosis

Mima, Kosuke; Nishihara, Reiko; Rong Qian, Zhi; Cao, Yin; Sukawa, Yasutaka; A. Nowak, Jonathan; Yang, Juhong; Dou, Ruoxu; Masugi, Yohei; Song, Mingyang; D. Kostic, Aleksandar; Giannakis, Marios; Bullman, Susan; A. Milner, Danny; Baba, Hideo; L. Giovannucci, Edward; A. Garraway, Levi; J. Freeman, Gordon; Dranoff, Glenn; S. Garrett, Wendy; Huttenhower, Curtis; Meyerson, Matthew; A. Meyerhardt, Jeffrey; T. Chan, Andrew; S. Fuchs, Charles; Ogino, Shuji

doi:10.1136/gutjnl-2015-310101

Public

Fusobacterium nucleatumin colorectal carcinoma tissue and patient prognosis

Published in Gut • Aug 26, 2015

Authors:

Kosuke Mima

Reiko Nishihara

Zhi Rong Qian

Abstract

OBJECTIVE: Accumulating evidence links the intestinal microbiota and colorectal carcinogenesis. Fusobacterium nucleatum may promote colorectal tumour growth and inhibit T cell-mediated immune responses against colorectal tumours. Thus, we hypothesised that the amount of F. nucleatum in colorectal ca...

Subject

Fusobacterium nucleatum

Colorectal cancer

Microsatellite instability

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