Inhibition of human DNA topoisomerase IB by nonmutagenic ruthenium( ii )-based compounds with antitumoral activity

S. de Camargo, Mariana; M. da Silva, Monize; S. Corrêa, Rodrigo; D. Vieira, Sara; Trini Castelli, Silvia; D'Anessa, Ilda; Aparecido De Grandis, Rone; A. Varanda, Eliana; M. Deflon, Victor; Desideri, Alessandro; A. Batista, Alzir

doi:10.1039/c5mt00227c

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Inhibition of human DNA topoisomerase IB by nonmutagenic ruthenium( ii )-based compounds with antitumoral activity

Published in Metallomics • Dec 23, 2015

Authors:

Mariana S. de Camargo

Monize M. da Silva

Rodrigo S. Corrêa

Abstract

Herein we synthesized two new ruthenium(II) compounds [Ru(pySH)(bipy)(dppb)]PF6 (1) and [Ru(HSpym)(bipy)(dppb)]PF6 (2) that are analogs to an antitumor agent recently described, [Ru(SpymMe2)(bipy)(dppb)]PF6 (3), where [(Spy) = 2-mercaptopyridine anion; (Spym) = 2-mercaptopyrimidine anion and (SpymMe...

Subject

Topoisomerase

DNA

Ruthenium

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