Hypomethylation of smoking-related genes is associated with future lung cancer in four prospective cohorts

Fasanelli, Francesca; Baglietto, Laura; Ponzi, Erica; Guida, Florence; Campanella, Gianluca; Johansson, Mattias; Grankvist, Kjell; Johansson, Mikael; Assumma, M; Naccarati, Alessio; Chadeau‐Hyam, Marc; Ala, Ugo; Faltus, Christian; Kaaks, Rudolf; Risch, Angela; De Stavola, Bianca; Hodge, Allison; G. Giles, Graham; C. Southey, Melissa; L. Relton, Caroline; Haycock, Philip; Lund, Eiliv; Polidoro, Silvia; M. Sandanger, Torkjel; Severi, Gianluca; Vineis, Paolo

doi:10.1038/ncomms10192

Public

Hypomethylation of smoking-related genes is associated with future lung cancer in four prospective cohorts

Published in Nature Communications • Dec 15, 2015

Authors:

Francesca Fasanelli

Laura Baglietto

Erica Ponzi

Abstract

DNA hypomethylation in certain genes is associated with tobacco exposure but it is unknown whether these methylation changes translate into increased lung cancer risk. In an epigenome-wide study of DNA from pre-diagnostic blood samples from 132 case-control pairs in the NOWAC cohort, we observe that...

Subject

Lung cancer

DNA methylation

Confounding

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