Adipocyte-Derived Hormone Leptin Is a Direct Regulator of Aldosterone Secretion, Which Promotes Endothelial Dysfunction and Cardiac Fibrosis

Huby, Anne-Cécile; Antonova, Galina; Groenendyk, Jake; E. Gómez-Sánchez, Celso; B. Bollag, Wendy; A. Filosa, Jessica; J. Belin de Chantemèle, Eric

doi:10.1161/circulationaha.115.018226

Public

Adipocyte-Derived Hormone Leptin Is a Direct Regulator of Aldosterone Secretion, Which Promotes Endothelial Dysfunction and Cardiac Fibrosis

Published in Circulation • Sep 11, 2015

Authors:

Anne-Cécile Huby

Galina Antonova

Jake Groenendyk

Abstract

BACKGROUND: In obesity, the excessive synthesis of aldosterone contributes to the development and progression of metabolic and cardiovascular dysfunctions. Obesity-induced hyperaldosteronism is independent of the known regulators of aldosterone secretion, but reliant on unidentified adipocyte-derive...

Subject

Aldosterone

Endocrinology

Internal medicine

Finding related papers...

Discussions

(0)

No comments yet

Be the first to share your thoughts!