Ovarian Suppression With Triptorelin During Adjuvant Breast Cancer Chemotherapy and Long-term Ovarian Function, Pregnancies, and Disease-Free Survival

Lambertini, Matteo; Boni, Luca; Michelotti, Andrea; Gamucci, Teresa; Scotto, Tiziana; Gori, Stefania; Giordano, Monica; Garrone, Ornella; Levaggi, Alessia; Poggio, Francesca; Giraudi, S.; Bighin, Claudia; Vecchio, Carlo; Roberto Sertoli, Mario; Pronzato, P.; Del Mastro, Lucia; the GIM Study Group, for

doi:10.1001/jama.2015.17291

Public

Ovarian Suppression With Triptorelin During Adjuvant Breast Cancer Chemotherapy and Long-term Ovarian Function, Pregnancies, and Disease-Free Survival

Published in JAMA • Dec 22, 2015

Authors:

Matteo Lambertini

Luca Boni

Andrea Michelotti

Abstract

IMPORTANCE: Whether the administration of luteinizing hormone-releasing hormone analogues (LHRHa) during chemotherapy is a reliable strategy to preserve ovarian function is controversial owing to both the lack of data on long-term ovarian function and pregnancies and the safety concerns about the po...

Subject

Triptorelin

Medicine

Hazard ratio

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