Inherited Mutations in Women With Ovarian Carcinoma

M. Norquist, Barbara; I. Harrell, Maria; F. Brady, Mark; Walsh, Tom; K. Lee, Ming; Gülsüner, Süleyman; S. Bernards, Sarah; Casadei, Silvia; Qian, Yi; A. Burger, Robert; K. Chan, John; A. Davidson, Susan; S. Mannel, Robert; DiSilvestro, Paul; A. Lankes, Heather; C. Ramirez, Nilsa; King, Mary‐Claire; M. Swisher, Elizabeth; J. Birrer, Michael

doi:10.1001/jamaoncol.2015.5495

Public

Inherited Mutations in Women With Ovarian Carcinoma

Published in JAMA Oncology • Dec 31, 2015

Authors:

Barbara M. Norquist

Maria I. Harrell

Mark F. Brady

Abstract

IMPORTANCE: Germline mutations in BRCA1 and BRCA2 are relatively common in women with ovarian, fallopian tube, and peritoneal carcinoma (OC) causing a greatly increased lifetime risk of these cancers, but the frequency and relevance of inherited mutations in other genes is less well characterized. O...

Subject

Medicine

Ovarian cancer

Fallopian tube cancer

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