Dysregulated YAP1/TAZ and TGF-β signaling mediate hepatocarcinogenesis in
                    <i>Mob1a/1b</i>
                    -deficient mice

Nishio, Miki; Sugimachi, Keishi; Goto, Hiroki; Wang, Jia; Morikawa, Takumi; Miyachi, Yosuke; Takano, Yusuke; Hikasa, Hiroki; Itoh, Tohru; O. Suzuki, Satoshi; Kurihara, Hiroki; Aishima, Shinichi; Leask, Andrew; Sasaki, Takehiko; Nakano, Toru; Nishina, Hiroshi; Nishikawa, Yuji; Sekido, Yoshitaka; Nakao, Kazuwa; Shin-ya, Kazuo; Mimori, Koshi; Suzuki, Akira

doi:10.1073/pnas.1517188113

Public

Dysregulated YAP1/TAZ and TGF-β signaling mediate hepatocarcinogenesis in Mob1a/1b -deficient mice

Shared by NobleBlocks on Dec 22, 2015 • 12:00 AM UTC

Authors:

Miki Nishio

Keishi Sugimachi

Hiroki Goto

Abstract

Significance Patients with intrahepatic cholangiocellular carcinoma (ICC) and combined hepatocellular and cholangiocarcinoma (cHC-CC) have worse prognoses than those with hepatocellular carcinoma and rarely show clinical responses to drugs. Our analyses of mice with liver-specific deletions of Mps O...

Research Assistant

AI chat, annotations, notes & similar papers

Finding related papers...

Discussions

(0)

No comments yet

Be the first to share your thoughts!