Tau Protein Hyperphosphorylation and Aggregation in Alzheimer’s Disease and Other Tauopathies, and Possible Neuroprotective Strategies

Šimić, Goran; Babić Leko, Mirjana; Wray, Selina; R. Harrington, Charles; Delalle, Ivana; Jovanov Milošević, Nataša; Bažadona, Danira; Buée, Luc; de Silva, Rohan; Di Giovanni, Giuseppe; M. Wischik, Claude; R. Hof, Patrick

doi:10.3390/biom6010006

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Tau Protein Hyperphosphorylation and Aggregation in Alzheimer’s Disease and Other Tauopathies, and Possible Neuroprotective Strategies

Published in Biomolecules • Jan 6, 2016

Authors:

Goran Šimić

Mirjana Babić Leko

Selina Wray

Abstract

Abnormal deposition of misprocessed and aggregated proteins is a common final pathway of most neurodegenerative diseases, including Alzheimer's disease (AD). AD is characterized by the extraneuronal deposition of the amyloid β (Aβ) protein in the form of plaques and the intraneuronal aggregation of ...

Subject

Tau protein

Hyperphosphorylation

Tau pathology

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