Singlet Oxygen-Mediated Oxidation during UVA Radiation Alters the Dynamic of Genomic DNA Replication

Graindorge, Dany; Martineau, Sylvain; Machon, Christelle; Arnoux, Philippe; Guitton, Jérôme; Francesconi, Stefania; Frochot, Céline; Sage, Évelyne; Girard, Pierre‐Marie

doi:10.1371/journal.pone.0140645

Public

Singlet Oxygen-Mediated Oxidation during UVA Radiation Alters the Dynamic of Genomic DNA Replication

Published in PLoS ONE • Oct 20, 2015

Authors:

Dany Graindorge

Sylvain Martineau

Christelle Machon

Abstract

UVA radiation (320-400 nm) is a major environmental agent that can exert its deleterious action on living organisms through absorption of the UVA photons by endogenous or exogenous photosensitizers. This leads to the production of reactive oxygen species (ROS), such as singlet oxygen (1O2) and hydro...

Subject

Singlet oxygen

Reactive oxygen species

DNA replication

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