Diverse and Targetable Kinase Alterations Drive Histiocytic Neoplasms

L. Diamond, Eli; H. Durham, Benjamin; Haroche, Julien; Yao, Zhan; Ma, Jing; A. Parikh, Sameer; Wang, Zhaoming; Choi, John; Hee Kim, Eun; Cohen‐Aubart, Fleur; Chun-Wei Lee, Stanley; Gao, Yijun; Micol, Jean‐Baptiste; Campbell, Patrick; P. Walsh, Michael; E. Sylvester, Brooke; Dolgalev, Igor; Aminova, Olga; Heguy, Adriana; Zappile, Paul; Nakitandwe, Joy; Ganzel, Chezi; Dalton, James; W. Ellison, David; Estrada‐Veras, Juvianee; E. Lacouture, Mario; A. Gahl, William; J. Stephens, Philip; A. Miller, Vincent; S. Ross, Jeffrey; M. Ali, Siraj; Briggs, Samuel; Fasan, Omotayo; Block, Jared; Héritier, Sébastien; Donadieu, Jean; B. Solit, David; M. Hyman, David; Baselga, José; Jankú, Filip; S. Taylor, Barry; Y. Park, Christopher; Amoura, Zahir; Doǧan, Ahmet; Emile, Jean‐François; Rosen, Neal; A. Grüber, Tanja; Abdel‐Wahab, Omar

doi:10.1158/2159-8290.cd-15-0913

Public

Diverse and Targetable Kinase Alterations Drive Histiocytic Neoplasms

Published in Cancer Discovery • Nov 13, 2015

Authors:

Eli L. Diamond

Benjamin H. Durham

Julien Haroche

Abstract

UNLABELLED: Histiocytic neoplasms are clonal, hematopoietic disorders characterized by an accumulation of abnormal, monocyte-derived dendritic cells or macrophages in Langerhans cell histiocytosis (LCH) and non-Langerhans cell histiocytosis (non-LCH), respectively. The discovery of BRAF(V600E) mutat...

Subject

Histiocytic sarcoma

Histiocyte

Langerhans cell histiocytosis

Research Assistant

AI chat, annotations, notes & similar papers

Finding related papers...

Discussions

(0)

No comments yet

Be the first to share your thoughts!