Shared Genetic Predisposition in Peripartum and Dilated Cardiomyopathies

S. Ware, James; Li, Jian; Mazaika, Erica; M. Yasso, Christopher; DeSouza, Tiffany; P. Cappola, Thomas; J. Tsai, Emily; Hilfiker‐Kleiner, Denise; Kamiya, Chizuko; Mazzarotto, Francesco; A. Cook, Stuart; Halder, Indrani; Prasad, Sanjay; Pisarcik, Jessica; Hanley‐Yanez, Karen; Alharethi, Rami; B. Damp, Julie; Hsich, Eileen; Elkayam, Uri; Sheppard, Richard; Kealey, Angela; D. Alexis, Jeffrey; Ramani, Gautam; Safirstein, Jordan; Boehmer, John; Pauly, Daniel; S. Wittstein, Ilan; Thohan, Vinay; Zucker, Mark; Liu, Peter; Gorcsan, John; M. McNamara, Dennis; E. Seidman, Christine; G. Seidman, Jonathan; Arany, Zoltàn

doi:10.1056/nejmoa1505517

Public

Shared Genetic Predisposition in Peripartum and Dilated Cardiomyopathies

Published in New England Journal of Medicine • Jan 6, 2016

Authors:

James S. Ware

Jian Li

Erica Mazaika

Abstract

Background Peripartum cardiomyopathy shares some clinical features with idiopathic dilated cardiomyopathy, a disorder caused by mutations in more than 40 genes, including TTN, which encodes the sarcomere protein titin. Methods In 172 women with peripartum cardiomyopathy, we sequenced 43 genes with v...

Subject

Dilated cardiomyopathy

Peripartum cardiomyopathy

Medicine

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