Activated Schwann cells in pancreatic cancer are linked to analgesia via suppression of spinal astroglia and microglia

Ekin Demir, İhsan; Tieftrunk, Elke; Schorn, Stephan; Cemil Saricaoglu, Ömer; L. Pfitzinger, Paulo; Teller, Steffen; Wang, Kun; Waldbaur, Christine; U. Kurkowski, Magdalena; M. Wörmann, Sonja; Shaw, Victoria; Kehl, Timo; Laschinger, Melanie; Costello, Eithne; Algül, Hana; Friess, Helmut; O. Ceyhan, Güralp

doi:10.1136/gutjnl-2015-309784

Public

Activated Schwann cells in pancreatic cancer are linked to analgesia via suppression of spinal astroglia and microglia

Published in Gut • Jan 13, 2016

Authors:

İhsan Ekin Demir

Elke Tieftrunk

Stephan Schorn

Abstract

OBJECTIVE: The impact of glia cells during GI carcinogenesis and in cancer pain is unknown. Here, we demonstrate a novel mechanism how Schwann cells (SCs) become activated in the pancreatic cancer (PCa) microenvironment and influence spinal activity and pain sensation. DESIGN: Human SCs were exposed...

Subject

Microglia

Pancreatic cancer

Medicine

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