ASCT2/SLC1A5 controls glutamine uptake and tumour growth in triple-negative basal-like breast cancer

van Geldermalsen, Michelle; Wang, Qian; Nagarajah, Rajini; D. Marshall, Amy; Thoeng, Annora; Gao, Dadi; Ritchie, William; Feng, Yongmei; G. Bailey, Charles; Deng, Niantao; Harvey, Kate; Beith, Jane; Selinger, Christina; O’Toole, Sandra; E.J. Rasko, John; Holst, Jeff

doi:10.1038/onc.2015.381

Public

ASCT2/SLC1A5 controls glutamine uptake and tumour growth in triple-negative basal-like breast cancer

Published in Oncogene • Oct 12, 2015

Authors:

Michelle van Geldermalsen

Qian Wang

Rajini Nagarajah

Abstract

Alanine, serine, cysteine-preferring transporter 2 (ASCT2; SLC1A5) mediates uptake of glutamine, a conditionally essential amino acid in rapidly proliferating tumour cells. Uptake of glutamine and subsequent glutaminolysis is critical for activation of the mTORC1 nutrient-sensing pathway, which regu...

Subject

Glutamine

Cancer research

Glutaminolysis

Research Assistant

AI chat, annotations, notes & similar papers

Finding related papers...

Discussions

(0)

No comments yet

Be the first to share your thoughts!