Analysis of Past and Present Synthetic Methodologies on Medicinal Chemistry: Where Have All the New Reactions Gone?

G. Brown, Dean; Boström, Jonas

doi:10.1021/acs.jmedchem.5b01409

Public

Analysis of Past and Present Synthetic Methodologies on Medicinal Chemistry: Where Have All the New Reactions Gone?

Published in Journal of Medicinal Chemistry • Nov 16, 2015

Authors:

Dean G. Brown

Jonas Boström

Abstract

An analysis of chemical reactions used in current medicinal chemistry (2014), three decades ago (1984), and in natural product total synthesis has been conducted. The analysis revealed that of the current most frequently used synthetic reactions, none were discovered within the past 20 years and onl...

Subject

Chemistry

Natural product

Nucleophilic aromatic substitution

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