Targeting of vascular cell adhesion molecule-1 by18F-labelled nanobodies for PET/CT imaging of inflamed atherosclerotic plaques

Bala, Gezim; Blykers, Anneleen; Xavier, Catarina; Descamps, Benedicte; Broisat, Alexis; Ghezzi, Cathérine; Fagret, Daniel; Van Camp, Guy; Caveliers, Vicky; Vanhove, Christian; Lahoutte, Tony; Droogmans, Steven; Cosyns, Bernard; Devoogdt, Nick; Hernot, Sophie

doi:10.1093/ehjci/jev346

Public

Targeting of vascular cell adhesion molecule-1 by18F-labelled nanobodies for PET/CT imaging of inflamed atherosclerotic plaques

Published in European Heart Journal - Cardiovascular Imaging • Jan 22, 2016

Authors:

Gezim Bala

Anneleen Blykers

Catarina Xavier

Abstract

AIMS: Positron emission tomography-computed tomography (PET-CT) is a highly sensitive clinical molecular imaging modality to study atherosclerotic plaque biology. Therefore, we sought to develop a new PET tracer, targeting vascular cell adhesion molecule (VCAM)-1 and validate it in a murine atherosc...

Subject

In vivo

Positron emission tomography

Ex vivo

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