Regulation of Memory Formation by the Transcription Factor XBP1

Martínez, Gabriela; L. Vidal, René; Mardones, Pablo; Serrano, Felipe; O. Ardiles, Álvaro; Wirth, Craig; Valdés, Pamela; Thielen, Peter; L. Schneider, Bernard; Kerr, Bredford; L. Valdés, José; G. Palacios, Adrián; C. Inestrosa, Nibaldo; H. Glimcher, Laurie; Hetz, Claudio

doi:10.1016/j.celrep.2016.01.028

Public

Regulation of Memory Formation by the Transcription Factor XBP1

Published in Cell Reports • Feb 1, 2016

Authors:

Gabriela Martínez

René L. Vidal

Pablo Mardones

Abstract

Contextual memory formation relies on the induction of new genes in the hippocampus. A polymorphism in the promoter of the transcription factor XBP1 was identified as a risk factor for Alzheimer's disease and bipolar disorders. XBP1 is a major regulator of the unfolded protein response (UPR), mediat...

Subject

XBP1

Transcription factor

Long-term potentiation

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