TGF-β/SMAD Pathway and Its Regulation in Hepatic Fibrosis

Xu, Fengyun; Liu, Changwei; Zhou, Dandan; Zhang, Lei

doi:10.1369/0022155415627681

Public

TGF-β/SMAD Pathway and Its Regulation in Hepatic Fibrosis

Published in Journal of Histochemistry & Cytochemistry • Jan 8, 2016

Authors:

Fengyun Xu

Changwei Liu

Dandan Zhou

Abstract

Transforming growth factor-beta1 (TGF-β1), a key member in the TGF-β superfamily, plays a critical role in the development of hepatic fibrosis. Its expression is consistently elevated in affected organs, which correlates with increased extracellular matrix deposition. SMAD proteins have been studied...

Subject

SMAD

Fibrosis

Transforming growth factor

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