Association between Functional Small Airway Disease and FEV1 Decline in Chronic Obstructive Pulmonary Disease

P. Bhatt, Surya; Soler, Xavier; Wang, Xin; Murray, Susan; Anzueto, Antonio; H. Beaty, Terri; M. Boriek, Aladin; Casaburi, Richard; J. Criner, Gerard; A. Díaz, Alejandro; T. Dransfield, Mark; Curran‐Everett, Douglas; J. Galbán, Craig; A. Hoffman, Eric; C. Hogg, James; A. Kazerooni, Ella; Kim, V.; L. Kinney, Gregory; Lagstein, Amir; A. Lynch, David; J. Make, Barry; J. Martínez, Fernando; Ramsdell, Joe; M. Reddy, Rishindra; D. Ross, Brian; B. Rossiter, Harry; M. Steiner, Robert; Strand, Matthew; J.R. van Beek, Edwin; S. Wan, Emily; R. Washko, George; Michael Wells, J.; H. Wendt, Chris; A. Wise, Robert; K. Silverman, Edwin; D. Crapo, James; P. Bowler, Russell; K. Han, MeiLan

doi:10.1164/rccm.201511-2219oc

Public

Association between Functional Small Airway Disease and FEV1 Decline in Chronic Obstructive Pulmonary Disease

Published in American Journal of Respiratory and Critical Care Medicine • Jan 25, 2016

Authors:

Surya P. Bhatt

Xavier Soler

Xin Wang

Abstract

RATIONALE: The small conducting airways are the major site of airflow obstruction in chronic obstructive pulmonary disease and may precede emphysema development. OBJECTIVES: We hypothesized a novel computed tomography (CT) biomarker of small airway disease predicts FEV1 decline. METHODS: We analyzed...

Subject

Medicine

Internal medicine

Obstructive lung disease

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