Liver PPARα is crucial for whole-body fatty acid homeostasis and is protective against NAFLD

Montagner, Alexandra; Polizzi, Arnaud; Fouché, Edwin; Ducheix, Simon; Lippi, Yannick; Lasserre, Frédèric; Barquissau, Valentin; Régnier, Marion; Lukowicz, Céline; Benhamed, Fadila; Iroz, Alison; Bertrand‐Michel, Justine; Al Saati, Talal; Cano‐Sánchez, Patricia; Mselli-Lakhal, Laïla; Mithieux, Gilles; Rajas, Fabienne; Lagarrigue, Sandrine; Pineau, Thierry; Loiseau, Nicolas; Postic, Catherine; Langin, Dominique; Wahli, Walter; Guillou, Hervé

doi:10.1136/gutjnl-2015-310798

Public

Liver PPARα is crucial for whole-body fatty acid homeostasis and is protective against NAFLD

Published in Gut • Feb 1, 2016

Authors:

Alexandra Montagner

Arnaud Polizzi

Edwin Fouché

Abstract

OBJECTIVE: Peroxisome proliferator-activated receptor α (PPARα) is a nuclear receptor expressed in tissues with high oxidative activity that plays a central role in metabolism. In this work, we investigated the effect of hepatocyte PPARα on non-alcoholic fatty liver disease (NAFLD). DESIGN: We const...

Subject

Internal medicine

Steatosis

Endocrinology

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