Periodontitis induced by <i>Porphyromonas gingivalis</i> drives periodontal microbiota dysbiosis and insulin resistance via an impaired adaptive immune response

Blasco‐Baqué, Vincent; Garidou, Lucile; Pomié, Celine; Escoula, Quentin; Loubières, Pascale; Le Gall‐David, Sandrine; Lemaitre, Mathieu; Nicolas, Simon; Klopp, Pascale; Waget, Aurélie; Azalbert, Vincent; Colom, André; Bonnaure‐Mallet, Martine; Kémoun, Philippe; Sérino, Matteo; Burcelin, Rémy

doi:10.1136/gutjnl-2015-309897

Public

Periodontitis induced by Porphyromonas gingivalis drives periodontal microbiota dysbiosis and insulin resistance via an impaired adaptive immune response

Published in Gut • Feb 2, 2016

Authors:

Vincent Blasco‐Baqué

Lucile Garidou

Celine Pomié

Abstract

Objective To identify a causal mechanism responsible for the enhancement of insulin resistance and hyperglycaemia following periodontitis in mice fed a fat-enriched diet. Design We set-up a unique animal model of periodontitis in C57Bl/6 female mice by infecting the periodontal tissue with specific ...

Subject

Porphyromonas gingivalis

Periodontitis

Dysbiosis

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