Safety and efficacy of AMG 655 in combination with paclitaxel and carboplatin (PC) in patients with advanced non-small cell lung cancer (NSCLC)

Paz‐Ares, Luis; Sanchez Torres, J.M.; Díaz-Padilla, Iván; Links, Matthew; Reguart, Noemı́; Boyer, Michael; S. Wiezorek, Jeffrey; Sabin, Tony; Pan, Yang; P. van Meerbeeck, Jan

doi:10.1200/jco.2009.27.15_suppl.e19048

Public

Safety and efficacy of AMG 655 in combination with paclitaxel and carboplatin (PC) in patients with advanced non-small cell lung cancer (NSCLC)

Published in Journal of Clinical Oncology • May 20, 2009

Authors:

Luis Paz‐Ares

J.M. Sanchez Torres

Iván Díaz-Padilla

Abstract

e19048 Background: AMG 655 is an investigational, fully human IgG1 monoclonal agonist antibody that binds human death receptor 5 (DR5), activates caspases, and induces apoptosis in sensitive tumor cells. The primary objective of this phase 1b study was to determine the maximum tolerated dose (up to ...

Subject

Medicine

Neutropenia

Pharmacokinetics

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