Amidated and Ibuprofen-Conjugated Kyotorphins Promote Neuronal Rescue and Memory Recovery in Cerebral Hypoperfusion Dementia Model

Sá Santos, Sónia; Santos, Sara; R. T. Pinto, Antónia; G. Ramu, Vasanthakumar; Heras, Montserrat; Bardajı́, Eduard; Tavares, Isaura; A. R. B. Castanho, Miguel

doi:10.3389/fnagi.2016.00001

Public

Amidated and Ibuprofen-Conjugated Kyotorphins Promote Neuronal Rescue and Memory Recovery in Cerebral Hypoperfusion Dementia Model

Published in Frontiers in Aging Neuroscience • Jan 26, 2016

Authors:

Sónia Sá Santos

Sara Santos

Antónia R. T. Pinto

Abstract

Chronic brain ischemia is a prominent risk factor for neurological dysfunction and progression for dementias, including Alzheimer's disease (AD). In rats, permanent bilateral common carotid artery occlusion (2VO) causes a progressive neurodegeneration in the hippocampus, learning deficits and memory...

Subject

Hippocampal formation

Hippocampus

Medicine

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