Use of HLA-B*58:01 genotyping to prevent allopurinol induced severe cutaneous adverse reactions in Taiwan: national prospective cohort study

Ko, Tai-Ming; Tsai, Chang‐Youh; Chen, Shih-Yang; Chen, Kuo-Shu; Yu, Kuang‐Hui; Chu, Chih‐Sheng; Huang, Chung‐Ming; Wang, Chrong‐Reen; Weng, Chia-Tse; Yu, Chia-Li; Hsieh, Song-Chou; Tsai, Jer-Chia; Lai, Wen-Ter; Tsai, Wen-Chan; Yin, Guang-Dar; Ou, Tsan‐Teng; Cheng, Kai‐Hung; Yen, Jeng‐Hsien; Liou, Teh-Ling; Lin, Tsung‐Hsien; Chen, Der-Yuan; Hsiao, Pi‐Jung; Weng, Meng‐Yu; Chen, Yi‐Ming; Chen, Chen-Hung; Liu, Ming-Fei; Yen, Hsueh-Wei; Lee, Jia‐Jung; Kuo, Mei-Chuan; Wu, Chen‐Ching; Hung, Shih‐Yuan; Luo, Shue‐Fen; Yang, Ya‐Hui; Chuang, Hui-Ping; Chou, Yi-Chun; Liao, Hung-Ting; Wang, Chia‐Wen; Huang, Chun-Lin; Chang, Chia-Shuo; Ta Michael Lee, Ming; Chen, Pei‐Jer; Wong, Chih‐Shung; Chen, Chien‐Hsiun; Wu, Jer-Yuarn; Chen, Yuan-Tsong; Shen, Chen‐Yang

doi:10.1136/bmj.h4848

Public

Use of HLA-B*58:01 genotyping to prevent allopurinol induced severe cutaneous adverse reactions in Taiwan: national prospective cohort study

Published in BMJ • Sep 23, 2015

Authors:

Tai-Ming Ko

Chang‐Youh Tsai

Shih-Yang Chen

Abstract

OBJECTIVE: To evaluate the use of prospective screening for the HLA-B*58:01 allele to identify Taiwanese individuals at risk of severe cutaneous adverse reactions (SCARs) induced by allopurinol treatment. DESIGN: National prospective cohort study. SETTING: 15 medical centres in different regions of ...

Subject

Allopurinol

Medicine

Scars

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