MAP4K family kinases act in parallel to MST1/2 to activate LATS1/2 in the Hippo pathway

Meng, Zhipeng; Moroishi, Toshiro; Mottier-Pavie, Violaine; W. Plouffe, Steven; Gram Hansen, Carsten; W. Hong, Audrey; Woo Park, Hyun; Mo, Jung-Soon; Lü, Wenqi; Lu, Shicong; Claudio Flores, Fabián; Yu, Fa‐Xing; Halder, Georg; Guan, Kun‐Liang

doi:10.1038/ncomms9357

Public

MAP4K family kinases act in parallel to MST1/2 to activate LATS1/2 in the Hippo pathway

Published in Nature Communications • Oct 5, 2015

Authors:

Zhipeng Meng

Toshiro Moroishi

Violaine Mottier-Pavie

Abstract

The Hippo pathway plays a central role in tissue homoeostasis, and its dysregulation contributes to tumorigenesis. Core components of the Hippo pathway include a kinase cascade of MST1/2 and LATS1/2 and the transcription co-activators YAP/TAZ. In response to stimulation, LATS1/2 phosphorylate and in...

Subject

Hippo signaling pathway

Phosphorylation

Kinase

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