Hereditary spastic paraplegia: Clinicogenetic lessons from 608 patients.

R, Schüle; S, Wiethoff; P, Martus; KN, Karle; S, Otto; S, Klebe; S, Klimpe; C, Gallenmüller; D, Kurzwelly; D, Henkel; F, Rimmele; H, Stolze; Z, Kohl; J, Kassubek; T, Klockgether; S, Vielhaber; C, Kamm; T, Klopstock; P, Bauer; S, Züchner; I, Liepelt-Scarfone; L, Schöls

doi:10.1002/ana.24611

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Hereditary spastic paraplegia: Clinicogenetic lessons from 608 patients.

Shared by NobleBlocks on Mar 11, 2016 • 12:00 AM UTC

Authors:

Schüle R

Wiethoff S

Martus P

Abstract

Objective Hereditary spastic paraplegias (HSPs) are genetically driven disorders with the hallmark of progressive spastic gait disturbance. To investigate the phenotypic spectrum, prognostic factors, and genotype-specific differences, we analyzed baseline data from a continuous, prospective cohort.M...

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