PTEN deficiency reprogrammes human neural stem cells towards a glioblastoma stem cell-like phenotype.

Duan, Shunlei; Yuan, Guohong; Liu, Xiaomeng; Ren, Ruotong; Li, Jingyi; Zhang, Weizhou; Wu, Jun; Xu, Xiuling; Fu, Lina; Li, Ying; Yang, Jiping; Zhang, Weiqi; Bai, Ruijun; Yi, Fei; Suzuki, Keiichiro; Gao, Hua; Rodriguez Esteban, Concepcion; Zhang, Chuanbao; Carlos Izpisua Belmonte, Juan; Chen, Zhiguo; Wang, Xiaomin; Jiang, Tao; Qu, Jing; Tang, Fuchou; Liu, Guang-Hui

doi:10.1038/ncomms10068

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PTEN deficiency reprogrammes human neural stem cells towards a glioblastoma stem cell-like phenotype.

Published in Nature communications • Dec 3, 2015

NobleIDark:/48914/w1/20260526/8C739816Record on NobleID

Authors:

Shunlei Duan

,

Guohong Yuan

,

Xiaomeng Liu

Abstract

PTEN is a tumour suppressor frequently mutated in many types of cancers. Here we show that targeted disruption of PTEN leads to neoplastic transformation of human neural stem cells (NSCs), but not mesenchymal stem cells. PTEN-deficient NSCs display neoplasm-associated metabolic and gene expression p...

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