A zebrafish melanoma model reveals emergence of neural crest identity during melanoma initiation

K. Kaufman, Charles; Mosimann, Christian; Peng Fan, Zi; Yang, Song; Thomas, Andrew; Ablain, Julien; L. Tan, Justin; Fogley, Rachel; van Rooijen, Ellen; J. Hagedorn, Elliott; Ciarlo, Christie; M. White, Richard; A. Matos, Dominick; Puller, Ann‐Christin; Santoriello, Cristina; C. Liao, Eric; A. Young, Richard; I. Zon, Leonard

doi:10.1126/science.aad2197

Public

A zebrafish melanoma model reveals emergence of neural crest identity during melanoma initiation

Published in Science • Jan 28, 2016

Authors:

Charles K. Kaufman

Christian Mosimann

Zi Peng Fan

Abstract

The "cancerized field" concept posits that cancer-prone cells in a given tissue share an oncogenic mutation, but only discreet clones within the field initiate tumors. Most benign nevi carry oncogenic BRAF(V600E) mutations but rarely become melanoma. The zebrafish crestin gene is expressed embryonic...

Subject

Neural crest

Zebrafish

Melanoma

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