Promoting Effect of Bile Acids on Colon Carcinogenesis After Intrarectal Instillation of N -Methyl- N ′ nitro- N -nitrosoguanidine in Rats 2

Narisawa, Tomio; E. Magadia, Napoleon; H. Weisburger, John; L. Wynder, Ernst

doi:10.1093/jnci/53.4.1093

Public

Promoting Effect of Bile Acids on Colon Carcinogenesis After Intrarectal Instillation of N -Methyl- N ′ nitro- N -nitrosoguanidine in Rats 2

Published in JNCI Journal of the National Cancer Institute • Oct 1, 1974

Authors:

Tomio Narisawa

Napoleon E. Magadia

John H. Weisburger

Abstract

The effect of 2 bile acids in colon carcinogenesis was studied in rats. A single dose of N-methyl-N′nitro- N-nitrosoguanidine (MNNG) was instilled intrarectally. Subsequently, repeated intrarectal doses of lithocholic or taurodeoxycholic acid were administered. Both bile acids increased the frequenc...

Subject

Lithocholic acid

Methylnitronitrosoguanidine

Carcinogenesis

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