Oxidation of the alarmin IL-33 regulates ST2-dependent inflammation

Suzanne Cohen, E.; C. Scott, Ian; B. Majithiya, Jayesh; Rapley, Laura; Kemp, Benjamin; England, Elizabeth; Gareth Rees, D.; L. Overed‐Sayer, Catherine; Woods, Joanne; J. Bond, Nicholas; Séguy Veyssier, Christel; J. Embrey, Kevin; A. Sims, Dorothy; Snaith, Michael; A. Vousden, Katherine; Strain, Martin; T. Y. Chan, Denice; Carmen, Sara; E. Chaillan Huntington, Catherine; Flavell, Liz; Xu, Jianqing; Popovic, Bojana; E. Brightling, Christopher; J. Vaughan, Tristan; Butler, Robin; C. Lowe, David; R. Higazi, Daniel; J. Corkill, Dominic; May, Richard; A. Sleeman, Matthew; Mustelin, Tomas

doi:10.1038/ncomms9327

Public

Oxidation of the alarmin IL-33 regulates ST2-dependent inflammation

Published in Nature Communications • Sep 14, 2015

Authors:

E. Suzanne Cohen

Ian C. Scott

Jayesh B. Majithiya

Abstract

In response to infections and irritants, the respiratory epithelium releases the alarmin interleukin (IL)-33 to elicit a rapid immune response. However, little is known about the regulation of IL-33 following its release. Here we report that the biological activity of IL-33 at its receptor ST2 is ra...

Subject

Inflammation

Interleukin 33

Cell biology

Research Assistant

AI chat, annotations, notes & similar papers

Finding related papers...

Discussions

(0)

No comments yet

Be the first to share your thoughts!