Cross-Comparison of Exome Analysis, Next-Generation Sequencing of Amplicons, and the iPLEX(®) ADME PGx Panel for Pharmacogenomic Profiling.

EW, Chua; SL, Cree; KN, Ton; K, Lehnert; P, Shepherd; N, Helsby; MA, Kennedy

doi:10.3389/fphar.2016.00001

Public

Cross-Comparison of Exome Analysis, Next-Generation Sequencing of Amplicons, and the iPLEX(®) ADME PGx Panel for Pharmacogenomic Profiling.

Shared by NobleBlocks on Jan 26, 2016 • 12:00 AM UTC

Authors:

Chua EW

Cree SL

Ton KN

Abstract

Whole-exome sequencing (WES) has been widely used for analysis of human genetic diseases, but its value for the pharmacogenomic profiling of individuals is not well studied. Initially, we performed an in-depth evaluation of the accuracy of WES variant calling in the pharmacogenes CYP2D6 and CYP2C19 ...

Subject

Whole-exome Sequencing

Multiplexed Genotyping Panel

Next-generation Amplicon Sequencing

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