Glucocorticoids limit acute lung inflammation in concert with inflammatory stimuli by induction of SphK1

Vettorazzi, Sabine; Bode, Constantin; Dejager, Lien; Frappart, Lucien; Shelest, Ekaterina; Klaßen, Carina; Tasdogan, Alpaslan; M. Reichardt, Holger; Libert, Claude; Schneider, Marion; Weih, Falk; Henriette Uhlenhaut, N.; David, Jean‐Pierre; H. Gräler, Markus; Kleiman, Anna; Tuckermann, Jan

doi:10.1038/ncomms8796

Public

Glucocorticoids limit acute lung inflammation in concert with inflammatory stimuli by induction of SphK1

Published in Nature Communications • Jul 17, 2015

Authors:

Sabine Vettorazzi

Constantin Bode

Lien Dejager

Abstract

Acute lung injury (ALI) is a severe inflammatory disease for which no specific treatment exists. As glucocorticoids have potent immunosuppressive effects, their application in ALI is currently being tested in clinical trials. However, the benefits of this type of regimen remain unclear. Here we iden...

Subject

Inflammation

Sphingosine kinase 1

Glucocorticoid receptor

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