Diagnostic Yield of Clinical Tumor and Germline Whole-Exome Sequencing for Children With Solid Tumors

Williams Parsons, D.; Roy, Angshumoy; Yang, Yaping; Wang, Tao; Scollon, Sarah; Bergstrom, Katie; A. Kerstein, Robin; Gutierrez, Stephanie; Petersen, Andrea; Bavle, Abhishek; Y. Lin, Frank; López‐Terrada, Dolores; A. Monzon, Federico; Hicks, John; W. Eldin, Karen; Quintanilla, Norma; M. Adesina, Adekunle; Mohila, Carrie; E. Whitehead, William; Jea, Andrew; A. Vasudevan, Sanjeev; G. Nuchtern, Jed; Ramamurthy, Uma; L. McGuire, Amy; G. Hilsenbeck, Susan; G. Reid, Jeffrey; M. Muzny, Donna; A. Wheeler, David; L. Berg, Stacey; Chintagumpala, Murali; M. Eng, Christine; A. Gibbs, Richard; E. Plon, Sharon

doi:10.1001/jamaoncol.2015.5699

Public

Diagnostic Yield of Clinical Tumor and Germline Whole-Exome Sequencing for Children With Solid Tumors

Published in JAMA Oncology • Jan 29, 2016

Authors:

D. Williams Parsons

Angshumoy Roy

Yaping Yang

Abstract

IMPORTANCE: Whole-exome sequencing (WES) has the potential to reveal tumor and germline mutations of clinical relevance, but the diagnostic yield for pediatric patients with solid tumors is unknown. OBJECTIVE: To characterize the diagnostic yield of combined tumor and germline WES for children with ...

Subject

Medicine

KRAS

Neuroblastoma RAS viral oncogene homolog

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