deconstructSigs: delineating mutational processes in single tumors distinguishes DNA repair deficiencies and patterns of carcinoma evolution

Rosenthal, Rachel; McGranahan, Nicholas; Herrero, Javier; S. Taylor, Barry; Swanton, Charles

doi:10.1186/s13059-016-0893-4

Public

deconstructSigs: delineating mutational processes in single tumors distinguishes DNA repair deficiencies and patterns of carcinoma evolution

Published in Genome biology • Feb 22, 2016

Authors:

Rachel Rosenthal

Nicholas McGranahan

Javier Herrero

Abstract

BACKGROUND: Analysis of somatic mutations provides insight into the mutational processes that have shaped the cancer genome, but such analysis currently requires large cohorts. We develop deconstructSigs, which allows the identification of mutational signatures within a single tumor sample. RESULTS:...

Subject

Biology

Genetics

Human genetics

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